top of page

Spravato (Esketamine) Intra-Nasal Depression Medication

SPRAVATO® is a prescription medicine used:

  • with or without an antidepressant taken by mouth, to treat adults with treatment-resistant depression (TRD)

  • with an antidepressant taken by mouth, to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions

SPRAVATO® is an  NMDA

 receptor antagonist believed to work differently from traditional antidepressants by acting on 

glutamate

.

  • The exact way SPRAVATO® works is unknown.

While the exact role of glutamate in depression is unknown, it is a chemical messenger found in the brain that is thought to help balance well-being and depression.

How Does It Work? 

You will administer SPRAVATO® nasal spray yourself under the supervision of a healthcare provider at a certified SPRAVATO® treatment center. Your healthcare provider will show you how to use the SPRAVATO® nasal spray device.

Screenshot 2025-10-10 at 7.26.48 PM.png
*Random Drug Screening for Controlled Substances is Required. 
bottom of page